张璞（博士，教授）
自2013年9月至2018年6月就读于西南大学化学化工学院，分析化学，硕博连读。自2018年7月至2021年11月，在以色列耶路撒冷希伯来大学化学系从事博士后研究，合作导师为中国科学院外籍院士Itamar Willner教授。主要研究领域为DNA纳米技术和新型核酸功能纳米材料，利用发光、电化学分析平台，实现了针对miRNA的传感、细胞成像及药物释放的诊疗一体化研究。迄今为止，共发表文章30余篇，以第一/通讯作者发表SCI文章19篇，其中影响因子大于15的文章5篇，包括J. Am. Chem. Soc. 1篇（高被引论文）、Angew. Chem. Int. Ed. 1 篇、ACS Nano 3篇、Chem. Sci. 4篇、Anal. Chem. 6篇、TrAC 1篇，他引次数1000余次，个人H因子16（基于谷歌学术）。于2021年荣获重庆市科学技术奖一等奖（参与人排名第4），荣获2019年重庆市优秀博士学位论文。主持国家自然科学基金、省部级自然科学基金共4项，省部级教改项目1项。多次指导学生参加“互联网+”项目，分别荣获全国铜奖、市级银奖和校级金奖，“挑战杯”重庆市特等奖。
联系方式 puzhang@swu.edu.cn
学科：分析化学。
研究方向：纳米材料，核酸纳米结构，纳米酶催化，人工细胞合成与应用；
电化学/发光分析，生物传感，荧光成像。
代表性论文
[1] Z. Yang, J. Zhou, F. Liu, Y. Chai, P. Zhang,* and Ruo Yuan*. CsPbBr3 Perovskite Quantum Dots Encapsulated by a Polymer Matrix for Ultrasensitive Dynamic Imaging of Intracellular MicroRNA. Anal. Chem., 2024, 96, 10738-10747.
[2] S. Bu, Li Song, Y. Ding, Y. Yang, Y. Liang, Y. Chai, P. Zhang,* Y. Fu,* R. Yuan*. Dual-Ligand Ruthenium Coordination Polymer-Derived SelfEnhanced Electrochemiluminescent Emitters for Sensitive Detection of Procalcitonin. Anal. Chem., 2024, 96, 10809-10816.
[3] Y. Ouyang,‡ P. Zhang,‡ I. Willner. DNA Tetrahedra as Functional Nanostructures: From Basic Principles to Applications. Angew. Chem. Int. Ed., 2024, e202411118. (first co-author)
[4] R. Meng , X. Zhang , J. Liu, Y. Zhou, P. Zhang,* Yaqin Chai,* Ruo Yuan.* Dual-layer 3D DNA nanostructure: The next generation of ultrafast DNA nanomachine for microRNA sensing and intracellular imaging. Biosens. Bioelectron., 2023, 237, 115517.
[5] P. Zhang,‡ Y. Ouyang,‡ Y. Zhuo, Y. Chai, R. Yuan,* Recent Advances in DNA Nanostructures Applied in Sensing Interfaces and Cellular Imaging. Anal. Chem., 2023, 95, 407-419.
[6] P. Zhang, Y. Zhuo, Y. Chai, R. Yuan.* Structural DNA tetrahedra and its electrochemical-related surface sensing. Trends in Anal. Chem., 2023, 160, 116979.
[7] P. Zhang, J. Jiang, R. Yuan,* Y. Zhuo,* Y. Chai.* Highly Ordered And Field-Free 3D DNA Nanostructure: The Next Generation of DNA Nanomachine for Rapid Single-Step Sensing. J. Am. Chem. Soc., 2018, 140, 9361-9364.
[8] P. Zhang, Y. Ouyang, Y. S. Sohn, M. Fadeev, O. Karmi, R. Nechushtai, I. Stein, E. Pikarsky, I. Willner.* miRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn (II)-Protoporphyrin IX-Loaded Metal-Organic Framework Nanoparticles. ACS nano, 2022, 16, 1791-1801.
[9] P. Zhang, Y. Ouyang, Y. S. Sohn, R. Nechushtai, E. Pikarsky, C. Fan, I. Willner.* pH-And miRNA-Responsive DNA-Tetrahedra/Metal-Organic Framework Conjugates: Functional Sense-And-Treat Carriers. ACS Nano, 2021, 15, 6645-6657.
[10] P. Zhang, L. Yue, M. Vazquez-Gonzalez, Z. Zhou, W.-H. Chen, Y. S. Sohn, R. Nechushtai, I. Willner.* MicroRNA-Guided Selective Release of Loads from Micro-/Nanocarriers Using Auxiliary Constitutional Dynamic Networks. ACS Nano, 2020, 14, 1482-1491.
[11] P. Zhang, A. Fischer, Y. Ouyang, Y. S. Sohn, R. Nechushtai, J. J. Zhang, H. Tian, C. H. Fan, I. Willner.* Biocatalytic Cascades and Intercommunicated Biocatalytic Cascades in Microcapsule Systems, Chem. Sci., 2022, 13, 7437-7448.
[12] P. Zhang, A. Fischer, Y. Ouyang, J. Wang, Y. S. Sohn, O. Karmi, R. Nechushtai, I. Willner.* Topologically switchable and gated transcription machinery, Chem. Sci., 2022, 13, 10555-10565.
[13] P. Zhang, A. Fischer, Y. Ouyang, J. Wang, Y. S. Sohn, R. Nechushtai, E. Pikarsky, C. Fan, I. Willner.* Aptamer-Modified DNA Tetrahedra-Gated Metal-Organic Framework Nanoparticle Carriers for Enhanced Chemotherapy or Photodynamic Therapy. Chem. Sci., 2021, 12, 14473-14483.
[14] P. Zhang, Y. Ouyang, I. Willner.* Multiplexed And Amplified Chemiluminescence Resonance Energy Transfer (CRET) Detection of Genes And microRNAs Using Dye-Loaded Hemin/G-quadruplex-Modified UiO-66 Metal-Organic Framework Nanoparticles. Chem. Sci., 2021, 12, 4810-4818.
