许文菊(Xu, Wenju)，博士(PhD)
教授(Professor)，博士生导师(Doctoral Supervisor)
西南大学 化学化工学院
电分析化学研究团队
发光分析与分子传感教育部重点实验室（西南大学）
个人简介：
l教育经历：2022.12~2023.6获国家留学基金委资助，在瑞典哥得堡大学化学与分子生物系知名教授Andrew G. Ewing实验室做高级访问学者研究；2013.10~2014.10获国家留学基金委资助，在美国堪萨斯大学化学系（生物分析化学Ralph N. Adams研究所）杰出教授George S. Wilson实验室做访问研究；2003.6/2009.6获西南师范大学/西南大学分析化学专业硕士/博士学位；1990.7获重庆大学材料学院学士学位。
●教学与教改：承担本科生《分析化学A》、《理化测试IA》、《分析化学B》与《分离富集技术》，硕士研究生《分离科学》及博士研究生《理论分析化学》等课程教学。主持教改项目两项，发表教改论文三篇。先后指导多名本科生荣获国家级、重庆市市级及西南大学校级创新创业训练项目。
l研究方向：生物传感器（Biosensors）、生物电分析化学（Bio-electroanalysis）及纳米生物技术（Nanobiotechnology）；致力于构建灵敏响应多样性光/电生物传感检测平台（Study on multiple sensitive responsive biosensor-based detection platforms）和新型功能DNA纳米结构组装及生物学性能研究（Design and construction of new functional DNA nanodevices and their biological features）。
l科研成果：主持在研项目：国家自然科学基金“环境内分泌干扰物暴露下乳腺癌多元标志物电化学检测新方法研究（22476162）”及重庆市自然科学基金面上项目“石墨炔纳米复合物协同双催化核酸放大构建超灵敏环境甾体雌激素电化学传感新方法研究（CSTB2024NSCQ-MSX0357）”。曾主持国家自然科学基金项目“环介导等温扩增H+诱导DNA纳米结构构型转换超灵敏HIV标志物DNA电化学生物传感器研究（21775123）”、重庆市自然科学基金项目“LAMP-H+诱导i-motif DNA信号转换构建高灵敏DNA电化学生物传感器研究（cstc2018jcyjA0774）”及校博士基金项目（SWU109026）。参研多项国家级及省部级项目。指导研究生中央高校基本科研业务费项目及多项本科生科技创新训练项目。近五年来，在国际著名期刊Analytical Chemistry，Biosensors Bioelectronics，Sensors & Actuators B等发表SCI一区论文近60篇；获两项国家授权发明专利（201911235748.9和201911423550.3）。
联系方式：
Email: xwju@swu.edu.cn
西南大学 29教307，重庆市北碚区天生路2号，400715
近几年代表性论文（selected publications）：
1. Jiayang He, Kexin Hu, Min Long, Chunli Yang, Yuqing Zhang, Xinyue Jia, Ruo Yuan, Wenju Xu*. Engineering fluorescence of guanine-activated Ag nanocluster to illuminate label-free, simplified and efficient logic circuits with minimal strand migration, Chem. Eng. J. 2025, 506, 159869.
2. Yuqing Zhang, Chunli Yang, Jiayang He, Zhihan Zhang, Yaqin Chai, Ruo Yuan, Wenju Xu*. Dynamic switching circuit modulated by intramolecular conformation transition of DNA translator for versatile fluorescence biosensors, Biosens. Bioelectron. 2025, Accepted, In press.
3. Honglin Song, Jingjing Ye, Yifu Zhou, Zhixuan Chen, Ruo Yuan, Wenju Xu*. DNA hairpin dimer-mediated dual-catalysis circuit for efficient and amplifiable electrochemical biosensing, Biosens. Bioelectron. 2025, 278, 117332.
4. Zhihan Zhang, Yuqing Zhang, Chunli Yang, Jiayang He, Xinyue Jia, Min Long, Ruo Yuan, Wenju Xu*. Target-responsive conformation switch of bihairpin molecular beacon to illustrate ratiometric fluorescence biosensing of dual-emissive silver nanoclusters, Anal. Chem. 2025, Accepted, In press.
5. Chunli Yang, Yuqing Zhang, Zhaorong Mo, Jiayang He, Zhihan Zhang, Yaqin Chai, Ruo Yuan, Wenju Xu*. A high-efficiency autocatalysis-oriented cascade circuit via reciprocal hug- amplification for assay-to-treat application. Anal. Chem. 2025, 97, 1816-1826
6. Jiayang He, Xin Shang, Min Long, Chunli Yang, Yuqing Zhang, Mengdie Li, Ruo Yuan, Wenju Xu*. Fluorescence biosensing based on bifurcated DNA scaffold-aggregated Ag nanocluster via responsive conformation switch of quasi-molecular beacon, Anal. Chem. 2024, 96, 3480-3488.
7. Chunli Yang, Yanan Shi, Yuqing Zhang, Jiayang He, Zhihan Zhang, Xinyue Jia, Ruo Yuan, Wenju Xu*. A bivariate fluorescence biosensor based on Janus DNA nanoarchitecture-loaded dual-emissive Ag nanoclusters as bi-responsive signaling reporters, Biosens. Bioelectron. 2024, 263, 116621.
8. Xinyue Jia, Jiayang He, Mengdie Li, Jingjing Ye, Yuqing Zhang, Chunli Yang, Ruo Yuan, Wenju Xu*. Stimulus-responsive four-stranded DNA nanoring assembly to host multiple nanosilver clusters for cooperatively enhanced fluorescence biosensing, Anal. Chem. 2024, 96, 10677-10685.
9. Jiayang He, Shihua Luo, Huilin Deng, Chunli Yang, Yuqing Zhang, Mengdie Li, Ruo Yuan, Wenju Xu*. Fluorescent features and applicable biosensing of a core-shell Ag nanocluster shielded by a DNA tetrahedral nanocage, Anal. Chem. 2023, 95, 14805-14815.
10. Yuqing Zhang, Chunli Yang, Jiayang He, Mengdie Li, Ruo Yuan, Wenju Xu*. Ratiometric fluorescence biosensing of tandem biemissive Ag clusters boosted by confined catalytic DNA assembly, Anal. Chem. 2023, 95, 17928-17936.
11. Chunli Yang, Yanan Shi, Yuqing Zhang, Jiayang He, Mengdie Li, Weixiang Huang, Ruo Yuan, Wenju Xu*. Modular DNA tetrahedron nanomachine-guided dual-responsive hybridization chain reactions for discernible bivariate assay and cell imaging, Anal. Chem. 2023, 95, 10337-10345.
12. Mengdie Li, Jiayang He, Xin Shang, Chunli Yang, Yuqing Zhang, Siyu Zuo, Ruo Yuan, Wenju Xu*. A Reciprocal-amplifiable fluorescence sensing platform via replicated hybridization chain reaction for hosting concatenated multi-Ag nanoclusters as signal reporter, Anal. Chem. 2022, 94, 16427-16435.
13. Yuqing Zhang, Chunli Yang, Jiayang He, Siyu Zuo, Xin Shang, Jiaxi Gao, Ruo Yuan, Wenju Xu*. Target DNA-activating proximity-localized catalytic hairpin assembly enables forming split-DNA Ag nanoclusters for robust and sensitive fluorescence biosensing, Anal. Chem. 2022, 94, 14947-14955.
14. Jiayang He, Huilin Deng, Xin Shang, Chunli Yang, Siyu Zuo, Ruo Yuan, Hongyan Liu, Wenju Xu*. Modulating fluorescence of silver nanocluster wrapped in DNA hairpin-loop via confined strand displacement and transient concatenate ligating for amplifiable biosensing, Anal. Chem. 2022, 94, 8041-8049.
15. Chunli Yang, Yuqing Zhang, Jiayang He, Mengdie Li, Ruo Yuan, Wenju Xu*. Target deoxyribonucleic acid-recycled lighting-up amplifiable ratiometric fluorescence biosensing of bicolor silver nanoclusters hosted in a switchable deoxyribonucleic acid construct, Anal. Chem. 2022, 94, 6703-6710.
16. Chunli Yang, Huilin Deng, Jiayang He, Xiaolong Zhang, Jiaxi Gao, Xin Shang, Siyu Zuo, Ruo Yuan, Wenju Xu*. Amplifiable ratiometric fluorescence biosensing of nanosilver multiclusters populated in three-way-junction DNA branches, Biosens. Bioelectron. 2022, 199, 113871.
17. Yumeng Liao, Jiaxi Gao, Weixiang Huang, Ruo Yuan, Wenju Xu*. LAMP-H+-responsive electrochemical ratiometric biosensor with minimized background signal for highly sensitive assay of specific short-stranded DNA, Biosens. Bioelectron. 2022, 195, 113662.
18. Jiayang He, Xin Shang, Chunli Yang, Siyu Zuo, Ruo Yuan, Wenju Xu*. Antibody-responsive ratiometric fluorescence biosensing of biemissive silver nanoclusters wrapped in switchable DNA tweezers, Anal. Chem. 2021, 93, 11634-11640.
