陈贵华
副教授，硕导
陈贵华，男，云南省华坪县人。2002-2006年就读于西南大学化学化工学院。2006年7月毕业，获理学学士学位。同年考取该院有机化学专业研究生，师从彭云贵教授，从事合成方法及手性药物合成研究。2009年7月获理学硕士学位。2009年进入中国科学院成都有机化学研究所攻读有机化学博士学位，师从廖建研究员，主要从事基于手性叔丁基亚砜的配体设计及过渡金属催化的不对称合成研究。2012年7月至2014年6月在北京大学化学与分子工程学院施章杰教授课题组从事惰性化学键转化研究。期间获中国博士后基金资助。在中国留学基金资助下，于2017年9月至2018年9月在瑞士洛桑联邦理工学院（EPFL）祝介平教授课题组进行访问学习。从2014年7月起进入西南大学化学化工学院从事有机化学相关的工作。先后主持中国博士后科学基金项目、西南大学博士基金（含引进人才计划）项目、西南大学教育教学改革研究项目、中央高校基本科研业务费项目和国家自然科学基金青年项目等。指导大学生创新创业项目3项（其中国创两项），中央高校基本科研业务费项目（学生）一项。迄今为止，已在Angew. Chem. Int. Ed、Nat. Commun.、Org. Lett.、Chem. Commun.、J. Org. Chem.等国际期刊上发表多篇学术论文，参编本科教材两本。
联系方式
chgh603@swu.edu.cn
研究方向
1、合成方法开发及生物活性化合物合成；2、工艺路线开发与优化
代表性论文：
1.Guihua Chen*, Jiajun Mo, Ding Jiang, Yungui Peng*. Synthesis of chiral 1,1,1-trifluoro-α,α-disubstituted 2,4-diketones via palladium-catalyzed asymmetric allylation,Org. Lett.2023,25, 2388.
2. Guihua Chen, Jian Cao (co-first author), Qian Wang, Jieping Zhu*. Desymmetrization of prochiral cyclopentenes enabled by enantioselective palladium-catalyzed oxidative Heck reaction, Org. Lett., 2020, 22, 322.
3. Ximeng Wei,Guihua Chen*, Yungui Peng*. Tandem nucleophilic addition/oxa-Michael reaction of ortho-formyl chalcones with dimethyl (diazomethyl)phosphonate for the synthesis of phosphine-containing 1,3-disubstituted phthalans,Tetrahedron Lett.,2020,61, 152174
4. Guihua Chen, Minglin Hu, Yungui Peng*. Switchable synthesis of 3-substituted 1H-indazoles and 3,3-disubstituted 3H-indazole-3-phosphonates tuned by phosphoryl groups, J. Org. Chem., 2018, 83, 1591.
5. Guihua Chen, Zhang-Jie Shi*. Privileged strategies for direct transformations of inert aliphatic C–H bonds, Natl. Sci. Rev., 2014, 1, 172.
6. Guihua Chen, Kang Chen, Zhang-Jie Shi*. Asymmetric allylic alkylation of alkene through direct C (sp3)-H functionalization, ChemCatChem. 2013, 5, 1289.
7. Guihua Chen, Jiangyang Gui, Peng Cao, Jian Liao*. Chiral sulfoxide-olefin ligands: tunable stereoselectivity in Rh-catalyzed asymmetric 1, 4-additions, Tetrahedron 2012, 68, 3220.
8. Guihua Chen, Junwei Xing, Peng Cao, Jian Liao*. Rh / chiral sulfinylphosphine catalyzed asymmetric 1, 4 – addition of arylboronic acids to chalcones, Tetrahedron 2012, 68, 5908. (Highlighted by Synfacts, 2012, 986).
9. Guihua Chen, Jiangyang Gui, Liangchun Li, Jian Liao*. Chiral sulfoxide-olefin ligands: completely switchable stereoselectivity in rhodium-catalyzed asymmetric conjugate additions, Angew. Chem. Int. Ed. 2011, 50, 7681. (Hot paper, Highlighted by Synfacts, 2011, 1193; Chin. J. Org. Chem. 2011, 31, 1961).
10. Feng Lang, Guihua Chen (co-first author), Liangchun Li, Junwei Xing, Fuzhong Han, Linfeng Cun, Jian Liao*. Rhodium-catalyzed highly enantioselective addition of arylboronic acids to 2-nitrostyrenes by tert-butanesulfinylphosphine ligand, Chem. Eur. J. 2011, 17, 5242. （Highlighted by Synfacts, 2011, 882).
11. Li-Sheng Zhang, Guihua Chen, Xin Wang, Qing-Yun Guo, Xi-Sha Zhang, Fei Pan, Kang Chen, Zhang-Jie Shi*. Direct borylation of primary C-H bonds in functionalized molecules by palladium catalysis, Angew. Chem. Int. Ed. 2014, 53, 3899.
12. Juanjuan Wang, Min Wang, Peng Cao, Liyin Jiang,Guihua Chen, and Jian Liao*. Rhodium-catalyzed asymmetric arylation of β,γ-unsaturated α-ketoamides for the construction of nonracemic γ,γ-diarylcarbonyl compounds, Angew. Chem. Int. Ed. 2014, 53, 6673.
13. Mingyu Yang, Bo Su, Yang Wang, Kang Chen, Xingyu Jiang, Yun-Fei Zhang, Xi-Sha Zhang,Guihua Chen, Ye Cheng, Zhichao Cao, Qing-Yun Guo, Lushun Wang, Zhang-Jie Shi*. Silver-catalysed direct amination of unactivated C–H bonds of functionalized molecules, Nat. Commun.2014, 5, 4707.
14. Xiangyang Zhang, Guihua Chen, Jibing Liu, Jian Liao*. Rhodium-catalyzed Michael addition of arylboronic acids to 3-alkylenyloxindoles: asymmetric synthesis of functionalized oxindoles, Tetrahedron Lett. 2012, 53, 438.
15.Jiangyang Gui, Guihua Chen, Peng Cao, Jian Liao*. Rh (I)-catalyzed asymmetric addition of arylboronic acids to NH Isatins, Tetrahedron: Asymmetry 2012, 23, 554.
16. Junwei Xing, Guihua Chen, Peng Cao, Jian Liao*. Rhodium-catalyzed asymmetric addition of arylboronic acids to indolylnitroalkenes, Eur. J. Org. Chem. 2012, 1230.
17. Jibing Liu, Guihua Chen, Junwei Xing, Jian Liao*. tert-Butanesulfinylthioether ligands: synthesis and application in palladium-catalyzed asymmetric allylic alkylation, Tetrahedron: Asymmetry, 2011, 22, 575.
18. Fuzhong Han, Guihua Chen, Xiangyang Zhang, Jian Liao*. Chiral heterodisulfoxide ligands in rhodium-catalyzed asymmetric 1, 4-addition of arylboronic acids to chromenones, Eur. J. Org. Chem. 2011, 2928.
19. Yongming Chuan, Guihua Chen, Jiuzhi Gao, Hui Zhang, Yungui Peng*. A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines, Chem. Commun. 2011, 47, 3260.
20. Yongming Chuan, Guihua Chen, Yungui Peng*. Highly enantioselective Michael addition reactions in water catalyzed by an insoluble MPS-supported 4-sulfonamidyl prolinol tert-butyldiphenylsilyl ether, Tetrahedron Lett. 2009, 50, 3054. (Highlighted by Synfacts, 2009, 926).
专著：
1. 袁亚利、刘章琴、陈贵华、钟霞、刘静主编，《有机化学实验》，西南师范大学出版社，2020年6月，普通高等学校一流专业建设规划教材.
2. 苏学素主编，张志扬、刘章琴、陈贵华 副主编，《有机化学》（第二版），西南大学出版社，2023年1月，普通高等学校一流专业建设规划教材.
