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许文菊
发布时间: 2015-12-22 14:55:21   作者:本站编辑   来源: 本站原创   浏览次数:


许文菊,博士

教授,博士生导师

西南大学 化学化工学院

电分析化学研究团队

发光分析与分子传感教育部重点实验室(西南大学)

个人简介:

l 教育经历:2013.10~2014.10获国家留学基金委资助,在美国堪萨斯大学化学系(生物分析化学Ralph N. Adams研究所)杰出教授George S. Wilson实验室做访问研究;2003.06/2009.06获西南师范大学/西南大学分析化学专业硕士/博士学位;1990.07获重庆大学材料学院学士学位。

l 教学与教改:承担本科生《分析化学A》、《理化测试IA》、《分析化学B》、《分离富集技术》,及研究生《分离科学》等课程教学;主持教改项目2项,发表教改论文3篇。

l 研究方向:生物传感器(Biosensors)、生物电分析化学(Bio-electroanalysis)及纳米生物技术(Nanobiotechnology);致力于构建灵敏响应多样性光/电生物传感检测平台(Study on multiple sensitive responsive biosensor-based detection platforms)和新型功能DNA纳米结构组装及生物学性能研究(Design and construction of new functional DNA nanodevices and their biological features)。

l 科研成果:主持国家自然科学基金面上项目(环介导等温扩增H+诱导DNA纳米结构构型转换超灵敏HIV标志物DNA电化学生物传感器研究,21775123)、重庆市自然科学基金基础研究与前沿探索项目(LAMP-H+诱导i-motif DNA信号转换构建高灵敏DNA电化学生物传感器研究,cstc2018jcyjA0774)、校博士基金项目(SWU109026);参研多项国家级及省部级项目;指导研究生中央高校基本科研业务费项目及多项本科生科技创新训练项目。近五年来,在国际著名期刊Analytical ChemistryBiosensors BioelectronicsChemical Communications等发表SCI一区论文30余篇;申请国家发明专利已受理2项(申请号201911235748.9201911423550.3)。

联系方式

Email: xwju@swu.edu.cn29教学楼307重庆市北碚区天生路2400715

代表性论文

1. Chong Li, Zehui Chen, Yuxuan Zhang, Jiayang He, Ruo Yuan, Wenju Xu*. Guanine-lighting- up fluorescence biosensing of silver nanoclusters populated in functional DNA constructs by a pH-triggered switch, Analytical Chemistry, 2020, 92, 13369-13377.

2. Jiayang He, Yuxuan Zhang, Zehui Chen, Chong Li, Ruo Yuan, Wenju Xu*. Targeted DNA- driven catalytic assembly light-up ratiometric fluorescence of biemissive silver nanoclusters for amplified biosensing, Chemical Communications, 2020, 56, 10325-10328.

3. Yumeng Liao, Shijing Guo, Xiaoyu Hua, Ruo Yuan, Wenju Xu*. Autocatalytic replicated Mg2+-ligation DNAzyme as robust biocatalyst for sensitive, label-free and enzyme-free electrochemical biosensing of protein, Sensors & Actuators: B. Chemical, 2020, 310, 127862.

4. Wenting Yang, Yu Shen, Danyang Zhang, Chong Li, Ruo Yuan, Wenju Xu*. Programmed dual-functional DNA tweezer for simultaneous and recognizable fluorescence detection of microRNA and protein, Analytical Chemistry, 2019, 91, 7782-7789.

5. Xiaoyu Hua, Enfen Yang, Wenting Yang, Ruo Yuan, Wenju Xu*. LAMP-generated H+ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA, Chemical Communications, 2019, 55, 12463-12466.

6. Chong Li, Wenting Yang, Ruo Yuan, Wenju Xu*. Antibody-responsive signal-off fluorescence of DNA-harbored silver nanoclusters for direct, rapid and sensitive immunoassay, Sensors & Actuators: B. Chemical, 2019, 301, 127148.

7. Xiaoyu Hua, Enfen Yang, Danyang Zhang, Yu Shen, Jianmin Zhao, Wenju Xu*. Proximity binding-induced DNA assembly as signal translator and enzymecatalyzed cleavage recycle as signal amplifier for highly sensitive electrochemical assay of target DNA, Sensors & Actuators: B. Chemical, 2019, 281, 864-870.

8. Wetting Yang, Yu Shen, Danyang Zhang, Wenju Xu*. Protein-responsive rolling circle amplification as tandem template to drive amplified transduction of fluorescence signal probes for highly sensitive bioanalysis, Chemical Communications, 2018, 54, 10195-10198.

9. Jianmin Zhao, Jiaxi Gao, Ting Zheng, Zhehan Yang, Yaqin Chai, Shihong Chen, Ruo Yuan, Wenju Xu*. Highly sensitive electrochemical assay for Nosema bombycis gene DNA PTP1 via conformational switch of DNA nanostructures regulated by H+ from LAMP, Biosensors and Bioelectronics, 2018, 106, 186-192.

10. Jianmin Zhao, Ting Zheng, Jiaxi Gao, Wenju Xu*. Toehold-mediated strand displacement reaction triggered by nicked DNAzymes substrate for amplified electrochemical detection of lead ion, Electrochimica Acta, 2018, 274, 16-22.

11. Xingxing Zhou, Shijing Guo, Jiaxi Gao, Jianmin Zhao, Shuyan Xue, Wenju Xu*. Glucose oxidase-initiated cascade catalysis for sensitive impedimetric aptasensor based on metal-organic frameworks functionalized with Pt nanoparticles and hemin/G-quadruplex as mimicking peroxidases, Biosensors and Bioelectronics, 2017, 98, 83-90.

12. Jianmin Zhao, Pei Jing, Shuyan Xue, Wenju Xu*. Dendritic structure DNA for specific metal ion biosensor based on catalytic hairpin assembly and a sensitive synergistic amplification strategy, Biosensors and Bioelectronics, 2017, 87, 157-163.

13. Wenju Xu*, Xingxing Zhou, Jiaxi Gao, Shuyan Xue, Jianmin Zhao. Label-free and enzyme-free strategy for sensitive electrochemical lead aptasensor by using metal-organic frameworks loaded with AgPt nanoparticles as signal probes and electrocatalytic enhancers, Electrochimica Acta, 2017, 251, 25-31.

14. Shuyan Xue, Pei Jing, Wenju Xu*. Hemin on graphene nanosheets functionalized with flower-like MnO2 and hollow AuPd for the electrochemical sensing lead ion based on the specific DNAzyme, Biosensors and Bioelectronics, 2016, 86, 958-965.

15. Xingxing Zhou, Shuyan Xue, Pei Jing, Wenju Xu*. A sensitive impedimetric platform biosensing protein: Insoluble precipitates based on the biocatalysis of manganese(III) meso-tetrakis (4-N-methylpyridiniumyl)-porphyrinin in HCR-assisted dsDNA, Biosensors and Bioelectronics, 2016, 86, 656-663.

16. Wenju Xu*, Pei Jing, Huayu Yi, Shuyan Xue, Ruo Yuan. Bimetallic Pt/Pd encapsulated mesoporous-hollow CeO2 nanospheres for signal amplification toward electrochemical peptide-based biosensing for matrix metalloproteinase 2, Sensors & Actuators: B. Chemical, 2016, 230, 345-352.

17. Wenju Xu*, Shuyan Xue, Huayu Yi, Pei Jing, Yaqin Chai, Ruo Yuan. A sensitive electrochemical aptasensor based on the co-catalysis of hemin/G-quadruplex, platinum nanoparticles and flower-like MnO2 nanosphere functionalized multi-walled carbon nanotubes, Chemical Communications, 2015, 51, 1472-1474.

18. Wenju Xu*, Huayu Yi, Yali Yuan, Pei Jing, Yaqin Chai, Ruo Yuan, George S. Wilson. An electrochemical aptasensor for thrombin using synergetic catalysis of enzyme and porous Au@Pd core-shell nanostructures for signal amplification, Biosensors and Bioelectronics, 2015, 64, 423-428.

19. Wenju Xu*, Yongmei Wu, Huayu Yi, Lijuan Bai, Yaqin Chai, Ruo Yuan. Porous platinum nanotubes modified with dendrimers as nanocarriers and electrocatalysts for sensitive electrochemical aptasensors based on enzymatic signal amplification, Chemical Communications, 2014, 50, 1451-1453.

20. Huayu Yi, Wenju Xu*, Yali Yuan, Lijuan Bai, Yongmei Wu, Yaqin Chai, Ruo Yuan. A pseudo triple-enzyme cascade amplified aptasensor for thrombin detection based on hemin/G- quadruplex as signal label, Biosensors and Bioelectronics, 2014, 54, 415-420.