欧阳煜，教授（含弘英才岗），博士生导师
2020年于南京理工大学获得博士学位； 2020年至2025年在以色列希伯来大学从事博士后研究工作，导师Itamar Willner教授（中科院外籍院士）。 2025年获聘西南大学化学化工学院教授（含弘英才岗）。现从事主要科研方向为纳米材料，DNA纳米技术，人工细胞与生物仿生，功能化纳米酶，化学与生物传感等。目前共发表SCI论文65篇，以第一/共一作者发表SCI论文19篇，包括Science Advances (1篇)，Nature Communications (1篇)，Journal of the American Chemical Society (5), Advanced Materials (1篇), Angewandte Chemie International Edition (2篇), ACS Nano (1篇) 等国际权威期刊，总引用次数3000余次，h-index 29。2020年荣获以色列Planning and Budgeting Committee (PBC) Fellowship博士后奖学金，在美国化学年会、以色列分析化学年会等国际会议作报告十余次，其中邀请报告一次。以指导教师身份指导西南大学本科生荣获第八届中国国际“互联网+”大学生创新创业大赛全国铜奖、第九届中国国际“互联网+”大学生创新创业大赛重庆赛区金奖，并获得第九届中国国际“互联网+”大学生创新创业大赛重庆赛区选拔赛“优秀创新创业导师”荣誉称号。
联系方式：yu.ouyang@mail.huji.ac.il
学科：分析化学
研究方向：DNA纳米技术；人工细胞与生物仿生；功能化纳米酶；化学与生物传感
本课题组长期招聘硕士、博士、博士后及科研助理，欢迎有志于从事相关研究的优秀同学加入！
代表性论文：
1.Xu, S.,# Ouyang, Y.,# Qin, Y. et al. Spatiotemporal dynamic and catalytically mediated reconfiguration of compartmentalized cyanuric acid/polyadenine DNA microdroplet condensates. Nat. Commun. 2025, 16, 3352. (共同一作)
2.Ouyang, Y., Willner, I. Photomodulated Transient Catalytic Constitutional Dynamic Networks and Reaction Circuits. Angew. Chem. Int. Ed. 2025, 64, e202420787.
3.Ouyang, Y., Zhang, P., Willner, I. DNA tetrahedra as functional nanostructures: from basic principles to applications. Angew. Chem. Int. Ed. 2024, 63, e202411118.
4.Ouyang, Y., Willner, I. Phototriggered equilibrated and transient orthogonally operating constitutional dynamic networks guiding biocatalytic cascades. J. Am. Chem. Soc., 2024, 146, 6806-6816.
5.Ouyang, Y., O'Hagan, M. P., Willner, B., & Willner, I. Aptamer‐Modified Homogeneous Catalysts, Heterogenous Nanoparticle Catalysts, and Photocatalysts: Functional “Nucleoapzymes”,“Aptananozymes”, and “Photoaptazymes”. Adv. Mater. 2024, 36, 2210885.
6.Ouyang, Y., Dong, J., & Willner, I. Dynamic DNA networks-guided directional and orthogonal transient biocatalytic cascades. J. Am. Chem. Soc., 2023, 145, 22135-22149.
7.Ouyang, Y.; Zhang, P.; Willner, I., Dissipative Biocatalytic Cascades and Gated Transient Biocatalytic Cascades Driven by Nucleic Acid Networks. Sci. Adv. 2022, 08, eabn3534.
8.Ouyang, Y.; Zhang, P.; Manis-Levy, H.; Paltiel, Y.; Willner, I., Transient Dissipative Optical Properties of Aggregated Au Nanoparticles, CdSe/ZnS Quantum Dots, and Supramolecular Nucleic Acid-Stabilized Ag Nanoclusters. J. Am. Chem. Soc. 2021, 143, 17622−17632.
9.Ouyang, Y.;# Biniuri, Y.;# Fadeev, M.; Zhang, P.; Carmieli, R.; Vazquez-Gonzalez, M.; Willner, I., Aptamer-Modified Cu2+-Functionalized C-Dots: Versatile Means to Improve Nanozyme Activities-"Aptananozymes". J. Am. Chem. Soc. 2021, 143, 11510-11519.
10.Zhou, Z.;# Ouyang, Y.;# Wang, J.; Willner, I., Dissipative Gated and Cascaded DNA Networks. J. Am. Chem. Soc. 2021, 143, 5071-5079. (共同一作)
11.Ouyang, Y.,# Fadeev, M.,# Zhang, P., Carmieli, R., Li, J., Sohn, Y.S., Karmi, O., Nechushtai, R., Pikarsky, E., Fan, C. and Willner, I., Aptamer-Modified Au Nanoparticles: Functional Nanozyme Bioreactors for Cascaded Catalysis and Catalysts for Chemodynamic Treatment of Cancer Cells. ACS nano, 2022, 16, 18232-18243.
12.Zhou, J., Liu, F., Han, Y., Li, H., Wei, S., Ouyang, Y.*, ... & Yuan, R.* Orderly aggregated catalytic hairpin assembly for synchronous ultrasensitive detecting and high-efficiency co-localization imaging of dual-miRNAs in living cells. Anal. Chem. 2023, 95(39), 14558-14565.
13.Han, Y., Zhou, J., Liu, F., Ouyang, Y.,* Yuan, R.,* Chai, Y. Q.* pH-stimulated self-locked DNA nanostructure for the effective discrimination of cancer cells and simultaneous detection and imaging of endogenous dual-MicroRNAs. Anal. Chem. 2023, 95, 12754-12760.
14.Ouyang, Y.,# O'Hagan, M.P. # and Willner, I., Functional catalytic nanoparticles (nanozymes) for sensing. Biosens. Bioelectron. 2022, 218, 114768.
15.Ouyang, Y.,# Fadeev, M.,# Zhang, P., Carmieli, R., Sohn, Y.S., Karmi, O., Qin, Y., Chen, X., Nechushtai, R. and Willner, I., Aptamer-Functionalized Ce4+-Ion-Modified C-Dots: Peroxidase Mimicking Aptananozymes for the Oxidation of Dopamine and Cytotoxic Effects toward Cancer Cells. ACS Appl. Mater. Interfaces 2022, 14, 55365-55375.
16.Ouyang, Y.; Zhang, P.; Willner, I., Dynamic Catalysis Guided by Nucleic Acid Networks and DNA Nanostructures. Bioconjugate Chem. 2022.
17.Fadeev, M.#; Ouyang, Y.#; Davidson-Rozenfeld, G. Willner, I., Controlling Electrocatalytic, Photoelectrocatalytic, and Release Processes Using Soft Material-Modified Electrodes. J. Electroanal. Chem. 2022, 904, 115926. (共同一作)
18.Zhang, P.; Ouyang, Y.; Sohn, Y. S.; Nechushtai, R.; Pikarsky, E.; Fan, C.; Willner, I., pH- and mNA-Responsive DNA-Tetrahedra/Metal-Organic Framework Conjugates: Functional Sense-and-Treat Carriers. ACS Nano 2021, 15, 6645-6657.
19.Zhang, P.; Ouyang, Y., Sohn, Y. S.; Fadeev, M.; Karmi, O.; Nechushtai, R.; Willner, I. miRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn (II)-Protoporphyrin IX-Loaded Metal–Organic Framework Nanoparticles. ACS Nano 2022, 16, 1791-1801.
20.Dong, J.; Ouyang, Y.; Wang, J.; O’Hagan, M. P.; Willner, I. Assembly of Dynamic Gated and Cascaded Transient DNAzyme Networks. ACS Nano. 2022, 16, 6153-6164.
21.Zhang, P.; Ouyang, Y.; Willner, I., Multiplexed and Amplified Chemiluminescence Resonance Energy Transfer (CRET) Detection of Genes and Micrornas Using Dye-Loaded Hemin/G-Quadruplex-Modified UiO-66 Metal-Organic Framework Nanoparticles. Chem. Sci. 2021, 12, 4810-4818.
