个人简介：

雷燕梅，副教授，硕士生导师；2014年至2020年于西南大学化学化工学院攻读并获得分析化学硕士和博士学位；2020年至2024年在上海交通大学医学院分子医学研究院从事博士后研究；2024年正式入职西南大学；长期围绕肿瘤早期诊断与精准治疗中的关键科学问题，深入开展基于微流控芯片、核酸纳米技术及多功能纳米材料的生物分析新方法、新技术研究；相关成果以第一作者/通讯作者发表于Angew. Chem. Int. Ed.、Sci. Adv.、Chem. Sci.、Anal. Chem.等国际期刊17篇；主持国家自然科学基金青年项目、重庆市自然科学基金面上项目、中国博士后科学基金面上项目及上海市超级博士后激励计划等；2026年荣获重庆市自然科学二等奖（排名第3）。

联系方式：

邮箱：leiyanmei6@swu.edu.cn

研究方向:

核酸分子诊疗；微流控芯片技术；电化学发光生物传感

近期代表性论文（#共同第一作者；*通讯作者）：

1.Guo, X. M.; Zhao, M. L.; Yang, X.; Zhong, X.; Lei, Y. M.*; Y. Zhuo*. Logic-Responsive Superspherical Nucleic Acid Enables Tumor-Specific Multiplexed Gene Silencing for Efficient Cancer Therapy. Angew. Chem. Int. Ed., 2026, e7096315.

2.Lei, Y. M.; ^# Fei, X. C.; ^# Ding, Y.; Zhang, J. H.; Zhang, G. H.; Dong, L.; Song, J.; Zhuo, Y.; ^* Xue, W.; ^* Zhang, P.; ^* Yang, C. Y.^* Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding. Sci. Adv. 2023, 9, eadi1556.

3.Lei, Y. M.; Wu, D.; Pan, M. C.; Tao, X., L.; Zeng, W., J.; Gan, L. Y.; Lei, D. L.; Chai, Y. Q.; Yuan, R.; Zhuo, Y.^* Dynamic Surface Reconstruction of Individual Gold Nanoclusters by Co-reactant Enables Color-tunable Electrochemiluminescence. Chem. Sci., 2024, 15, 3255-3261.

4.Chen Z. P.; Wang L. X.; Zhou X. M.; Luo X. Y.; Lei Y. M.^*; Zhuo Y^*. Dichromatically Encoded DNA Nanodevice for High-Resolution Molecular Subtyping of Triple-Negative Breast Cancer. Anal Chem. 2026, 98, 14585-14593.

5.Yan L.; Tao X. L.; Wang Z.; Yang W. W.; Li W.; Lei, Y. M.^*; Zhuo, Y.^* In Situ-Generated Dual-Catalytic DNAzyme Walkers for High-Fidelity Electrochemiluminescence Detection of FEN1 Activity. Anal. Chem. 2025, 25810-25817.

6.Tan, L. Q.; Zeng, W. J.; Chen, Q. L.; Tao, X. L.; Yuan, R.; Lei, Y. M.^*; Zhuo, Y.^* Programmable Split DNAzyme Modulators via Allosteric Cooperative Activation for mRNA Electrochemiluminescence Biosensing. Anal. Chem. 2025, 97 (10), 5789-5797.

7.Yang, F.^*, Jiang, X. Y., Tan, C.; Yuan, R.; Lei, Y. M.^*; Zhuo, Y.^* Steric Engineering of Perylene Derivative Side Chains to Boost Electrochemiluminescence for High-Performance Bioanalysis. Anal. Chem. 2025, 97，8813-8820.

8.Lei, Y. M.;^# Zhao, L. D.; ^# Li, Y. H.; Yuan, R.; Zhong, X.^*; Zhuo, Y.^* Self-Replicating Catalytic Hybridization Assembly of Bipedal DNAzyme Walkers for Enhanced Electrochemiluminescence Bioanalysis. Anal. Chem. 2024, 96 (44), 17850-17858.

9.Tang J. H.; Liu W.; Gao M. H.; Guo, X. M.; Lei, Y. M.^*; Zhuo, Y.^* Specific Response Assembly of 3D Space-Confined DNA Nano-Aggregates for Rapid and Sensitive Detection of DNA Methyltransferase. Anal. Chem. 2024, 96 (52), 20665-20673.

10.Gao, M. H.; Yang, X. H.; Tang, J. H.; Zhou, X. M.; Lei, Y. M.^*; Zhuo, Y.^* Selective Activation of Cascade Assembly Amplification for DNA Methyltransferase Detection Using a Double-Loop Interlocked DNA Circuit. Anal. Chem. 2024, 96 (30), 12546-12552.